Keywords: almost disjoint families; small uncountable cardinals; iterations of ψ; Hausdorff; Urysohn.

Understanding the impact of the p53 tumor suppressor pathway on the regulation of genome integrity, cancer development, and cancer treatment has intrigued scientists and clinicians for decades. It appears that the p53 pathway is a central node for nearly all cell stress responses, including: gene expression, DNA repair, cell cycle arrest, metabolic adjustments, apoptosis, and senescence. In the past decade, it has become increasingly clear that p53 function is directly regulated by poly(ADP‐ribose) polymerase‐1 (PARP‐1), a nuclear enzyme involved in DNA (...) repair signaling. Here, we will discuss the impact of PARP‐1 on p53 function, along with a recently described novel role for the reciprocal regulation of p53 regulated, PARP‐1 dependent necrosis following DNA damage. (shrink)

When applied in the health sector, AI-based applications raise not only ethical but legal and safety concerns, where algorithms trained on data from majority populations can generate less accurate or reliable results for minorities and other disadvantaged groups.

This paper explores the difference between Connectionist proposals for cognitive a r c h i t e c t u r e a n d t h e s o r t s o f m o d e l s t hat have traditionally been assum e d i n c o g n i t i v e s c i e n c e . W e c l a i m t h a t t h (...) e m a j o r d i s t i n c t i o n i s t h a t , w h i l e b o t h Connectionist and Classical architectures postulate representational mental states, the latter but not the former are committed to a symbol-level of representation, or to a ‘language of thought’: i.e., to representational states that have combinatorial syntactic and semantic structure. Several arguments for combinatorial structure in mental representations are then reviewed. These include arguments based on the ‘systematicity’ of mental representation: i.e., on the fact that cognitive capacities always exhibit certain symmetries, so that the ability to entertain a given thought implies the ability to entertain thoughts with semantically related contents. We claim that such arguments make a powerful case that mind/brain architecture is not Connectionist at the cognitive level. We then consider the possibility that Connectionism may provide an account of the neural (or ‘abstract neurological’) structures in which Classical cognitive architecture is implemented. We survey a n u m b e r o f t h e s t a n d a r d a r g u m e n t s t h a t h a v e b e e n o f f e r e d i n f a v o r o f Connectionism, and conclude that they are coherent only on this interpretation. (shrink)

Joseph Blado critiqued my probabilistic arguments against Roman papal doctrines by deploying probability arguments, particularly Bayesian arguments, in favor of the papacy. He contends that there are good C-inductive arguments for papal doctrine that, taken together, add up to a good P-inductive argument. I argue that his inductive arguments fail, and moreover that there are three good C-inductive arguments against papal doctrine in the neighborhood of his failed arguments. I conclude by critiquing his retreat to what he calls ‘skeptical papalism’ (...) as a last ditch sort of move to defend papal doctrine. (shrink)

Trata-se do capítulo “Overdetermined Oedipus: Mommy, Daddy, and Me as Desiring-Machine” in: BUCHANAN, Ian. (Org). A Deleuzian Century?. Durham: Duke University Press, 1999. (N.T.).

Este artigo analisa as políticas e estratégias da Santa Sé para criar novas circunscrições eclesiásticas durante a gestão do núncio apostólico Alessandro Bavona, que atuou entre 1907 e 1911. Serão enfocadas as relações entre a Santa Sé, que formulava projetos para reformar, fortalecer e expandir a Igreja Católica, e o episcopado brasileiro, que, muitas vezes, resistiu, colocou obstáculos e retardou o avanço dessas políticas. As fontes foram obtidas no _Arquivo Apostólico Vaticano_ e no _Arquivo Histórico da Sagrada Congregação dos Trabalhos (...) Eclesiásticos Extraordinários_. A criação de jurisdições eclesiásticas atendia a interesses civis e, sobretudo, eclesiásticos, pois pretendia ordenar o território e a gestão episcopal, dividindo as dioceses mais extensas, com maior ou menor densidade demográfica, a fim de tornar eficaz a assistência religiosa, disciplinar o clero, combater as religiões concorrentes, cristianizar as populações indígenas. A excepcional expansão institucional que ocorreu durante a gestão de Bavona favoreceu a ampliação da presença da Igreja Católica na sociedade e seu controle religioso. (shrink)

Until the end of the early 1970s, from a history of economic thought perspective, the mainstream in economics was pluralist, but once neoclassical economics became totally dominant it claimed the mainstream as its own. Since then, alternative views and schools of economics increasingly became minorities in the discipline and were considered heterodox. This book is in honour of John Edward King who has an impressive publication record in the area of economic theory with specific interest in how economic thought in (...) the past shapes current economic theory and enforces certain paths of economic policy and economic development. This book is divided into five themes based on King s interests. The first theme looks at the challenge in trying to reclaim pluralism in economics. The second faces head-on the direct collision of mainstream economics with history of economic thought and heterodox economics. The third addresses classical economic ideas, their central influence in the past and how they can still primarily guide modern pluralist economics. The fourth examines Post Keynesian and Kaleckian economics with a view to providing a more coherent and extensive branch of heterodox economics. The final theme critiques the policy of neoliberalism that has entrenched itself in capitalist economies which have led to financial, industrial, labour, and behavioural/consumerist crises. This text aims to provide a clear path for pluralism to serve the economics discipline as its standard bearer, and to no longer be merely a heterodox challenge to the mainstream. This book is of interest to those who study history of economic thought, political economy and heterodox economics. ". (shrink)

This article studies the etiquette diffusion and the reform of behavior during the pastoral visit of D. Carlos Luiz D'Amour, south of the Diocese of Cuiabá, in 1886. The source is the diary written by the private secretary Canon Bento Severiano da Luz. In such diary, the paths of the party were narrated as well as its major events and achievements, having the bishop as the central character. One of the objectives of the trip was to spread new patterns of (...) behavior, feelings and etiquette, civilize Mato Grosso and establish a good Catholic society. The public appearances of the bishop had symbolic functions, i.e, the political and religious affirmation of the episcopal power in society, creating a sacred sphere embodied in his person. D. Carlos, in the game of power relations, sees himself compelled to submit to the etiquette as well as to pressure the diocesans to do the same. Every detail of the etiquette and the ceremonial has fulfilled the function of ostentatious self-representation. His suppression has abolished distances, the social distinctions and obliterated his authority and power. (shrink)

1 There is a Standard Objection to the idea that concepts might be prototypes (or exemplars, or stereotypes): Because they are productive, concepts must be compositional. Prototypes aren't compositional, so concepts can't be prototypes (see, e.g., Margolis, 1994).2 However, two recent papers (Osherson and Smith, 1988; Kamp and Partee, 1995) reconsider this consensus. They suggest that, although the Standard Objection is probably right in the long run, the cases where prototypes fail to exhibit compositionality are relatively exotic and involve phenomena (...) which any account of compositionality is likely to find hard to deal with; for example, the effects of quantifiers, indexicals, contextual constraints, etc. KP are even prepared to indulge a guarded optimism: "... when a suitably rich compositional theory... is developed, prototypes will be seen ... as one property among many which only when taken altogether can support a compositional theory of combination" (p.56). In this paper, we argue that the Standard Objection to prototype theory was right after all: The problems about compositionality are insuperable in even the most trivial sorts of examples; it is therefore as near to certain as anything in cognitive science ever gets that the structure of concepts is not statistical. Theories of categorization, concept acquisition, lexical meaning and the like, which assume the contrary simply don't work. We commence with a general discussion of the constraints that an account of concepts must meet if their compositionality is to explain their productivity. We'll then turn to a criticism of proposals that OS2 and KP make for coping with some specific cases. (shrink)

O artigo analisa os posicionamentos de D. Francisco de Aquino Corrêa, arcebispo de Cuiabá, sobre o Brasil e a defesa do patriotismo cristão. Como um dos porta vozes da hierarquia eclesiástica brasileira e da Santa Sé, conquistou grande projeção e influência social entre as décadas de 1910 e 1940. As referências empíricas são os discursos e as cartas pastorais do período de 1920 a 1940. D. Aquino repensava e defendia novas formas de participação e de valorização da Igreja Católica como (...) força legitimadora do poder, enquanto instituição disciplinadora da sociedade e como defensora do caráter nacional e do processo Diálogos civilizatório brasileiro. (shrink)

This book presents views of the concept of intention and its relationship to communication from three perspectives: philosphy, linguistics, and artificial intelligence. The book is a record of a workshop held in 1987.

Apresenta-se neste artigo o papel desempenhado pelo bispo e arcebispo de Cuiabá Dom Francisco de Aquino Corrêa na construção da identidade mato-grossense, entre as décadas de 1910 a 1930. Como governador de Mato Grosso, interveio na esfera cultural a fim de fortalecer as elites cuiabanas e superar as crises política, econômica e social. Para tal, arregimentou um grupo de intelectuais que se empenharam na construção da identidade regional assentada na idealização das terras e do homem mato-grossense, superando os estigmas de (...) fronteira-sertão. Para tal, criou o Instituto Histórico e Geográfico de Mato Grosso e a Academia Mato-grossense de Letras, símbolos regionais, e realizou sucessivas manifestações culturais. Como membro da hierarquia eclesiástica, empenhou-se em recuperar o prestígio da Igreja Católica, valorizar os aspectos religiosos da cultura brasileira e propagar o regionalismo, o nacionalismo e o culto à nação. (shrink)

Zen students described their experiences when working with koans, and a phenomenological method was used to identify the structure of those experiences. Zen koans are statements or stories developed in China and Japan by Zen masters in order to help students transform their conscious awareness of the world. Eight participants including 3 females and 5 males from Southern California with 1 to 30 years of experience in Zen answered open-ended questions about koan practice in one tape-recorded session for each participant. (...) Refl ection yielded the following thematic clusters: (a) motivation, (b) approaches to working with koans, (c) experiences while working with koans, (d) experiences of insight into koans, (e) working with a teacher, and (f ) transformation. Participants described positive transformations including better control of emotions and concentration, better awareness of prejudices and biases with the ability to suppress those types of habitual associations, and a new relation to and acceptance of spiritual questions and doubts. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Aristotle on Shame and Learning to Be Good by Marta JimenezJerry GreenMarta Jimenez. Aristotle on Shame and Learning to Be Good. Oxford: Oxford University Press, 2021. Pp. 224. Hardback, $70.00.Aristotle on Shame and Learning to Be Good is a close examination of an underappreciated topic in Aristotle's theories of moral psychology and moral development: shame. Jimenez argues that shame is a sui generis emotion that plays a crucial (...) role in the habituation of moral virtue in young humans who are not yet virtuous and therefore cannot fully see the moral landscape as accurately as the fully developed virtuous adult. On this view, shame acts as a protovirtue that orients the developing moral agent toward "the noble" (τό καλόν), using social cues to learn not only what actions should be avoided or performed, but also what makes those actions shameful or noble, allowing them to eventually see beyond these external correlates of the noble and develop a grasp of nobility itself. Shame is therefore an indispensable tool for cultivating the emotional, perceptual, and cognitive abilities of a person on the path to virtue.The treatment of shame presented here is meant to bridge what Jimenez calls the "moral upbringing gap." On the one hand, nonvirtuous people are able to engage in the same behavior as virtuous people: they can, in principle, eat moderately, stand firm in battle, use their money judiciously, and so on, in a way that is externally indistinguishable from the virtuous. But there is no guarantee that performing these behaviors will lead the nonvirtuous person to develop the psychological traits necessary to perform virtuous actions as the virtuous person does them, with the correct motivation, emotion, and reasoning (e.g. performing a virtuous action enthusiastically, because it is the right thing to do, in a clear-eyed, informed way). Jimenez argues that shame can bridge this gap between action and affect by using signs like the disapproval of others or the depictions of literary exemplars such as epic heroes, not only to see what actions should be done or avoided, but also to begin to appreciate how and why these actions are in fact noble. So understood, shame is directed at the noble itself, not merely at the things that tend to be superficially associated with the noble (such as the pleasures of social praise or the inconveniences of ill repute).The chapters of this short book naturally fall into three groups. The first section (chapters 1 and 2) focuses on common interpretations of shame's role in Aristotle's ethics and objections to these interpretations. Chapter 1 studies the moral upbringing gap discussed above, with emphasis on moral motivation; chapter 2 focuses on the role of pleasure and pain. Both chapters draw heavily on classic works on the topic, such as Miles Burnyeat's "Aristotle on Learning to Be Good" (in Essays on Aristotle's Ethics, ed. A. O. Rorty [Berkeley: University of California Press, 1980], 69-92) and Nancy Sherman's The Fabric of Character (Oxford: Oxford University Press, 1989).The middle section of the book describes the nuances of moral development in Aristotle's moral psychology. Chapter 3 is a case study on the varieties of states that resemble courage; this chapter may initially appear to be a digression, but it highlights the many distinct psychological components of true virtue, giving us a better sense of just how complex the path toward moral development is, and hence what role shame would need to play in this development. Chapter 4 focuses on honor, with special attention paid to the importance of genuine approbation of praiseworthy actions from reputable sources.The final section of the book examines shame itself and the indispensable role it plays in moral development. Chapter 5 argues that shame is a sui generis emotion, not quite a full disposition (hexis), but more than a mere passion (pathos). This chapter also argues that we need not posit any special distinctions to harmonize two key passages on shame from books IV.9 and X.9 of the Nicomachean Ethics that may appear to be in tension. Chapter 6 shows how shame operates in moral development and why it is a... (shrink)

Reason and quest for revelation, by P. Tillich.--On the ontological mystery, by G. Marcel.--The problem of non-objectifying thinking and speaking, by M. Heidegger.--The problem of natural theology, by J. Macquarrie.--Metaphysical rebellion, by A. Camus.--Psychoanalysis and religion by E. Fromm.--Why I am not a Christian, by B. Russell.--The quest for being, by S. Hook.--The sacred and the profane; a dialectical understanding of Christianity, by T. J. J. Altizer.--Three strata of meaning in religious discourse by C. Hartshorne.--The theological task, by J. B. (...) Cobb.--Theology and objectivity, by S. A. Ogden.--Can faith validate God-talk? by K. Nielsen.--The logic of God, by J. Wisdom.--Mapping the logic of models in science and theology, by F. Ferré.--On understanding mystery, by I. T. Ramsey.--Teilhard de Chardin; a philosophy of precession, by E. R. Baltazar.--The nature of apologetics, by H. Bouillard.--Metaphysics as horizon, by B. Lonergan.--Deciding whether to believe, by M. Novak. (shrink)

Ubiquitous computing is a new kind of computing where devices enhance everyday artefacts and open up previously inaccessible situations for data capture. ‘Technology paternalism’ has been suggested by Spiekermann and Pallas (Poiesis & Praxis: Int J Technol Assess Ethics Sci 4(1):6–18, 2006) as a concept to gauge the social and ethical impact of these new technologies. In this article we explore this concept in the specific setting of UK road maintenance and construction. Drawing on examples from our qualitative fieldwork we (...) suggest that cultural logics such as those reflected in paternalistic health and safety discourse are central in legitimising the introduction of ubiquitous computing technologies. As such, there is little doubt that paternalism plays an essential role in people’s reasoning about ubiquitous computing in this setting. We argue, however, that since discourses such as health and safety are used by everyone (including both managers and workers) in the organisation to further their own aims, technologies transcend purely paternalistic conceptualisations and instead become a focal point for ongoing struggles for control between those deploying and using them. This means that the benefits and costs of such new technologies become harder to define from an ethical and social perspective. (shrink)

We question whether Plamondon & Alimi's model is useful in accounting for the nonsymmetrical and multiple-peaked velocity profiles observed in young and elderly subjects for ballistic aiming tasks. For these subjects, both data and observation suggest that a central representation initiates the movement in an appropriate direction but that multiple adjustments are made, both early and late, to achieve spatial accuracy.

When people learn normative systems, they do so based on limited evidence. Many of the possible actions that are available to an agent have never been explicitly permitted or prohibited. But people will often need to figure out whether those unspecified actions are permitted or prohibited. How does a learner resolve this incompleteness? The learner might assume if an action-type is not expressly forbidden, then acts of that type are permitted. This closure principle is one of Liberty. Alternatively, the learner (...) might assume that if an action-type is not expressly permitted, then acts of that type are prohibited. This closure principle would be one of Residual Prohibition (Mikhail, 2011). On the basis of principles of pedagogical sampling (e.g., Shafto, Goodman, & Griffiths, 2014), we predicted that participants would infer the Liberty Principle (LP) when trained on prohibitions, and they would infer the Residual Prohibition Principle when trained on permissions. This is exactly what we found across several experiments. We also found a bias in favor of Liberty insofar as participants trained on both a prohibition and a permission rule tended still to infer the LP. However, we also found that if an action is potentially harmful, this diminishes the tendency to infer the LP. (shrink)

For forty years, Harvey Mansfield has been worth reading. Whether plumbing the depths of MachiavelliOs Discourses or explaining what was at stake in Bill ClintonOs impeachment, MansfieldOs work in political philosophy and political science has set the standard. In Educating the Prince, twenty-one of his students, themselves distinguished scholars, try to live up to that standard. Their essays offer penetrating analyses of Machiavellianism, liberalism, and America., all of them informed by MansfieldOs own work. The volume also includes a bibliography of (...) MansfieldOs writings. (shrink)

Activation of gene transcription in vivo is accompanied by an alteration of chromatin structure. The specific binding of transcriptional activators disrupts nucleosomal arrays, suggesting that the primary steps leading to transcriptional initiation involve interactions between activators and chromatin. The affinity of transcription factors for nucleosomal DNA is determined by the location of recognition sequences within nucleosomes, and by the cooperative interactions of multiple proteins targeting binding sites contained within the same nucleosomes. In addition, two distinct types of enzymatic complexes facilitate (...) binding of transcription factors to nucleosomal DNA. These include type A histone acetyltransferases (e.g. GCN5/ADA transcriptional adaptor complex) and ATP‐driven molecular machines that disrupt histone‐DNA interactions (e.g. SWI/SNF and NURF complexes). These observations raise the important question of what happens to the histones during chromatin remodeling. We discuss evidence supporting the retention of histones at transcription factorbound sequences as well as two alternative pathways of histone loss from gene control elements upon transcription factor binding: histone octamer sliding and histone dissociation. (shrink)

This study investigates professional tax practitioners' ethical judgments and behavioral intentions in cases involving client pressure to adopt aggressive reporting positions, an issue that has been identified as the most difficult ethical/moral problem facing public accounting practitioners. The multidimensional ethics scale (MES) was used to measure the extent to which a hypothetical behavior was consistent with five ethical philosophies (moral equity, contractualism, utilitarianism, relativism, and egoism). Responses from a sample of 67 tax professionals supported the existence of all dimensions of (...) the MES other than egoism. Regressions of ethical judgments and behavioral intentions on the MES dimensions indicate that ethical decision making is most heavily influenced by the moral equity dimension, followed by the contractualism dimension. In contrast, the utilitarianism and relativism dimensions were only related to ethical judgments and behavioral intentions in isolated instances. (shrink)

Risk prediction in emergency medicine (EM) holds unique challenges due to issues surrounding urgency, blurry research-practise distinctions, and the high-pressure environment in emergency departments (ED). Artificial intelligence (AI) risk prediction tools have been developed with the aim of streamlining triaging processes and mitigating perennial issues affecting EDs globally, such as overcrowding and delays. The implementation of these tools is complicated by the potential risks associated with over-triage and under-triage, untraceable false positives, as well as the potential for the biases of (...) healthcare professionals toward technology leading to the incorrect usage of such tools. This paper explores risk surrounding these issues in an analysis of a case study involving a machine learning triage tool called the Score for Emergency Risk Prediction (SERP) in Singapore. This tool is used for estimating mortality risk in presentation at the ED. After two successful retrospective studies demonstrating SERP’s strong predictive accuracy, researchers decided that the pre-implementation randomised controlled trial (RCT) would not be feasible due to how the tool interacts with clinical judgement, complicating the blinded arm of the trial. This led them to consider other methods of testing SERP’s real-world capabilities, such as ongoing-evaluation type studies. We discuss the outcomes of a risk–benefit analysis to argue that the proposed implementation strategy is ethically appropriate and aligns with improvement-focused and systemic approaches to implementation, especially the learning health systems framework (LHS) to ensure safety, efficacy, and ongoing learning. (shrink)

Artificial intelligence (AI) has attracted an increasing amount of attention, both positive and negative. Its potential applications in healthcare are indeed manifold and revolutionary, and within the realm of medical imaging and radiology (which will be the focus of this paper), significant increases in accuracy and speed, as well as significant savings in cost, stand to be gained through the adoption of this technology. Because of its novelty, a norm of keeping humans “in the loop” wherever AI mechanisms are deployed (...) has become synonymous with good ethical practice in some circles. It has been argued that keeping humans “in the loop” is important for reasons of safety, accountability, and the maintenance of institutional trust. However, as the application of machine learning for the detection of lumbar spinal stenosis (LSS) in this paper’s case study reveals, there are some scenarios where an insistence on keeping humans in the loop (or in other words, the resistance to automation) seems unwarranted and could possibly lead us to miss out on very real and important opportunities in healthcare—particularly in low-resource settings. It is important to acknowledge these opportunity costs of resisting automation in such contexts, where better options may be unavailable. Using an AI model based on convolutional neural networks developed by a team of researchers at NUH/NUS medical school in Singapore for automated detection and classification of the lumbar spinal canal, lateral recess, and neural foraminal narrowing in an MRI scan of the spine to diagnose LSS, we will aim to demonstrate that where certain criteria hold (e.g., the AI is as accurate or better than human experts, risks are low in the event of an error, the gain in wellbeing is significant, and the task being automated is not essentially or importantly human), it is both morally permissible and even desirable to kick the humans out of the loop. (shrink)

Despite widespread interest in the topic of moral repair in the business ethics literature and in the workplace, little is currently known about moral repair with regard to the self—i.e., how and why individuals repair themselves in the aftermath of harming others within workplace contexts and what factors may influence the success of self-repair. We conducted a qualitative study in the context of health care organizations to develop an inductive model of self-repair in the workplace. Our findings reveal a set (...) of factors, including reactions to the harm incident, motivating factors, and methods of self-repair that involve intrapersonal (e.g., self-compassion) and interpersonal (e.g., seeking feedback and support from co-workers and managers) actions. We discovered that self-repair, or what we characterize as “moral self-repair” is a complex process characterized by important ethical, emotional, and social dimensions and that the effectiveness of self-repair actions is moderated by the actions of those within the organization (e.g., co-workers, managers) and outside the organization (e.g., families, friends, counselors). These social actors can promote self-repair by offering encouragement and support, or undermine self-repair by communicating a lack of trust and respect that reinforces self-blame. This model of self-repair is intended to guide future ethics research on the topic of moral self-repair and offers insight to practicing managers. (shrink)

This article reviews recent developments in health care law, focusing on the engagement of law as a partner in health care innovation. The article addresses: the history and contents of recent United States federal law restricting the use of genetic information by insurers and employers; the recent federal policy recommending routine HIV testing; the recent revision of federal policy regarding the funding of human embryonic stem cell research; the history, current status, and need for future attention to advance directives; the (...) recent emergence of medical–legal partnerships and their benefits for patients; the obesity epidemic and its implications for the child’s right to health under international conventions. (shrink)

In his book Why Not Socialism?, G.A. Cohen described several kinds of inequality that would be acceptable under socialism, yet nonetheless harmful to community. I describe another kind of inequality with this property, deriving from the legitimate transmission of preferences and values from parents to children. In the same book, Cohen proposes that the designing of a socialist allocation mechanism is a key problem for socialist theory. I maintain this is less of a problem than he believes. Finally, some thoughts (...) on the “law of motion of socialist ethos” are offered. (shrink)

Proponents of non-conceptual content have recruited it for various philosophical jobs. Some epistemologists have suggested that it may play the role of “the given” that Sellars is supposed to have exorcised from philosophy. Some philosophers of mind (e.g., Dretske) have suggested that it plays an important role in the project of naturalizing semantics as a kind of halfway between merely information bearing and possessing conceptual content. Here I will focus on a recent proposal by Jerry Fodor. In a recent (...) paper he characterizes non-conceptual content in a particular way and argues that it is plausible that it plays an explanatory role in accounting for certain auditory and visual phenomena. So he thinks that there is reason to believe that there is non-conceptual content. On the other hand, Fodor thinks that non-conceptual content has a limited role. It occurs only in the very early stages of perceptual processing prior to conscious awareness. My paper is examines Fodor’s characterization of non-conceptual content and his claims for its explanatory importance. I also discuss if Fodor has made a case for limiting non-conceptual content to non-conscious, sub-personal mental states. (shrink)